Zokardis 7.5 tablets coated.pl.ob. 7.5 mg, 28 pcs. (zofenopril)
Special Price
$22.10
Regular Price
$26.00
In stock
SKU
newyork463718
Latin name
Zocardis Buy Zokardis 7.5 tablets coated.pl.ob. 7.5 mg, 28 pcs. (zofenopril) in newyork free shipping. Fast international shipping USA, AU, EU, UK and others.
Zocardis Buy Zokardis 7.5 tablets coated.pl.ob. 7.5 mg, 28 pcs. (zofenopril) in newyork free shipping. Fast international shipping USA, AU, EU, UK and others.
Latin name
Zocardis
Release form
film-coated tablets.
Packing
28 pcs
Pharmacological action
Pharmacodynamics
ACE inhibitor, antihypertensive drug. The mechanism of action is associated with a decrease in the formation of angiotensin II from angiotensin I. A decrease in the content of angiotensin II leads to a direct decrease in the release of aldosterone, while OPSS, systolic and diastolic blood pressure, post- and myocardial preload are reduced. Expands arteries to a greater extent than veins, while a reflex increase in heart rate is not observed. Reduces the degradation of bradykinin, increases the synthesis of prostaglandin.
The antihypertensive effect is more pronounced with a high concentration of plasma renin than with a normal or reduced concentration. A decrease in blood pressure in the therapeutic range does not affect cerebral circulation, blood flow in the vessels of the brain is maintained at a sufficient level and against a background of decreased blood pressure. Enhances coronary and renal blood flow.
With prolonged use, hypertrophy of the left ventricle of the myocardium and myocytes of the walls of the arteries of the resistive type, prevents the progression of heart failure and slows down the development of dilatation of the left ventricle. Improves blood supply to the ischemic myocardium. Reduces platelet aggregation. Zofenopril is a prodrug, because free sulfhydryl compound (zofenoprilat), resulting from thioether hydrolysis, has activity.
After oral administration, the hypotensive effect develops after 1 hour, reaches a maximum after 4-6 hours and lasts up to 24 hours. In some cases, therapy is required for several weeks to achieve an optimal reduction in blood pressure. In heart failure, a noticeable clinical effect is observed with prolonged treatment (6 months or more).
Pharmacokinetics
Absorption and distribution of
After oral administration, zofenopril is rapidly and completely absorbed from the gastrointestinal tract and undergoes almost complete conversion to zofenoprilat.
Cmax of zofenoprilat in blood plasma is achieved 1.5 hours after taking Zokardis. Plasma protein binding for zofenopril is 88%.
Metabolism and excretion
Zofenopril is rapidly metabolized in the liver to form the active metabolite of zofenopril. T1 / 2 of zofenoprilat is 5.5 hours, the total clearance is 1300 ml / min. Zofenoprilat is excreted mainly by the kidneys - 69%, through the intestines - 26%.
Indications
Mild to moderate arterial hypertension.
Acute myocardial infarction with symptoms of heart failure in patients with stable hemodynamics and not receiving thrombolytic therapy.
Contraindications
Hypersensitivity to zofenopril and other ACE inhibitors
angioedema associated with the use of ACE inhibitors, a history of
porphyria
severe liver dysfunction
early pregnancy early
severe renal failure.
Caution is advised to use Zokardis®: with primary hyperaldosteronism, bilateral renal artery stenosis, single kidney artery stenosis, hyperkalemia, condition after kidney transplantation, aortic stenosis, mitral stenosis (with hemodynamic impairment), idiopathic hypertrophic subaortic stenosis, connective tissue disease, cerebrovascular disease, cerebrovascular disease proteinuria more than 1 g / day), liver failure, with simultaneous use with immunosuppressants, in the elderly (art. Arsha 75 years old), with psoriasis.
Caution must be exercised when prescribing the drug to patients with reduced BCC (as a result of diuretic therapy, while restricting salt intake, hemodialysis, diarrhea and vomiting), because increased risk of a sudden and pronounced decrease in blood pressure after the use of an ACE inhibitor, even at the initial dose.
Use during pregnancy and lactation
ZocardiВ® is contraindicated in pregnancy and lactation (breastfeeding).
When using the drug, women of childbearing age should use reliable methods of contraception.
Zofenopril calcium is excreted in breast milk.
Composition
1 tablet contains:
Active substances:
zofenopril calcium 7.5 mg.
Excipients:
lactose monohydrate,
magnesium stearate,
microcrystalline cellulose,
corn starch,
silicon dioxide colloidal.
Shell composition:
hypromellose,
titanium dioxide,
macrogol 400,
macrogol 600.
Dosage and administration of
Tablets are taken orally, regardless of the meal (before, during or after a meal), drinking plenty of fluids.
Arterial hypertension
Patients with normal liver and kidney function
Adults should begin with a dose of 15 mg (2 tablets of 7.5 mg or 1/2 tablet of 30 mg) 1 time / day and gradually to achieve the optimal level of blood pressure. , with insufficient severity of the hypotensive effect, increase the dose with an interval of 4 weeks.
The average dose is 30 mg 1 time / day (4 tablets of 7.5 mg or 1 tablet of 30 mg).
The maximum daily dose is 60 mg (8 tablets of 7.5 mg or 2 tablets of 30 mg). Multiplicity of admission is 1-2 times / day.
Patients with impaired water-electrolyte balance
Before prescribing ACE inhibitors, correction of water-electrolyte metabolism and cancellation of diuretic therapy 2–3 days before the start of ACE inhibitor are required. In this case, the initial dose of Zocardis is 15 mg / day. If the abolition of diuretics and normalization of the water-electrolyte balance is not possible, then the initial dose of Zokardis should be 7.5 mg / day.
Patients with impaired renal function or undergoing hemodialysis
Zocardis dose adjustment is required. With KK> 45 ml / min dose adjustment is not performed, with KK < 45 ml / min dose should be reduced to 1/2 the average therapeutic dose 1 time / day.
The starting dose for dialysis patients is 1/4 of the dose used for patients with normal renal function.
Elderly patients
With normal renal function, dosage adjustment in the elderly is not required. Elderly patients with CC <45 ml / min are recommended 1/2 of the average therapeutic dose.
Patients with impaired liver function
In patients with mild to moderate hepatic insufficiency, the initial dose of Zokardis® is 1/2 the dose used in patients with normal liver function.
Patients with severe hepatic impairment
Zokardis® is not prescribed.
Acute myocardial infarction
Treatment with Zokardis® is started within 24 hours after the onset of the first symptoms of myocardial infarction and continues for 6 weeks, with the following regimen applied:
Time period 1 and 2 days 7.5 mg every 12 hours (dosing regimen).
Time period 3rd and 4th day, 15 mg every 12 hours (dosing regimen).
Time period from the 5th day onwards to 30 mg every 12 hours (dosing regimen).
With an excessive decrease in blood pressure at the beginning of treatment or during the first 3 days after myocardial infarction, the initial dose is not increased or the drug is canceled.
After 6 weeks of treatment, therapy may be discontinued in patients with no evidence of left ventricular failure or heart failure. For the correction of left ventricular failure or heart failure, as well as hypertension, treatment can be continued for a long time.
Dosage in elderly patients with acute myocardial infarction
Zokardis® should be used with caution in patients with myocardial infarction older than 75 years.
Side effects of
From the cardiovascular system: excessive decrease in blood pressure, orthostatic collapse rarely - pain behind the sternum, angina pectoris, myocardial infarction (usually associated with a pronounced decrease in blood pressure), arrhythmias (atrial brady or tachycardia, atrial fibrillation), palpitations, thromboembolism of the branches of the pulmonary artery, pain in the heart, fainting.
From the side of the central nervous system and peripheral nervous system: dizziness, headache, weakness, insomnia, anxiety, depression, confusion, increased fatigue, drowsiness (2-3%) is very rare (when used in high doses) - nervousness, paresthesia.
On the part of the sensory organs: rarely - disturbances in the vestibular apparatus, impaired hearing and vision, tinnitus.
From the digestive system: dry mouth, anorexia, dyspeptic disorders (nausea, diarrhea or constipation, vomiting, abdominal pain), increased activity of liver transaminases, hyperbilirubinemia, intestinal obstruction, pancreatitis, impaired liver function, disorders of the biliary tract, hepatitis, jaundice.
From the respiratory system: unproductive dry cough is very rare - interstitial pneumonitis, bronchospasm, shortness of breath, rhinorrhea, pharyngitis.
From the hemopoietic system: in some cases, thrombocytopenia, neutropenia, agranulocytosis (in patients with autoimmune diseases), eosinophilia.
From the urinary system: increased creatinine and urea, impaired renal function, proteinuria.
On the part of laboratory indicators: hypercreatinemia, increased urinary levels, increased activity of AST, ALT, hyperbilirubinemia, hyperkalemia, hyponatremia, in some cases, decreased hematocrit and decreased hemoglobin, increased ESR, thrombocytopenia, neutropenia, agranulocytosis, and patients with .
Allergic reactions: rarely - skin rash, angioedema (face, limbs, lips, tongue, glottis and / or larynx), dysphonia, polymorphic erythema, exfoliative dermatitis very rarely - Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell syndrome) , pemphigus, itching, urticaria, photosensitivity, serositis, vasculitis, myositis, arthralgia, arthritis, stomatitis, glossitis.
Drug Interaction
When used jointly, the antihypertensive effect of ACE inhibitors may be enhanced by other antihypertensive agents, diuretics, general anesthesia agents, antipyretics, ethanol.
When administered with NSAIDs, the antihypertensive effect of zofenopril may be reduced.
Hyperkalemia may occur when co-administered with potassium-sparing diuretics.
When used simultaneously with lithium salts, there is a slowdown in lithium removal.
When used together with immunosuppressants, allopurinol, cytostatics enhance the hematotoxicity of zofenopril.
When administered with hypoglycemic agents, the risk of hypoglycemia increases.
Overdose
Symptoms: marked decrease in blood pressure (up to the development of collapse, myocardial infarction, acute disorders of cerebral circulation or thromboembolic complications), convulsions, stupor.
Treatment: the patient is transferred to a horizontal position with a low head. In mild cases - gastric lavage and intake of saline solution, in more severe cases, measures aimed at stabilizing blood pressure (in / in the introduction of 0.9% sodium chloride solution, plasma substitutes), if necessary - the introduction of angiotensin II, hemodialysis.
Storage conditions
Keep out of the reach of children at a temperature not exceeding 25 ° C.
Expiration
3 years.
Deystvuyuschee substances
zofenopril
Terms of sale from pharmacies s17lfpd17 pharmacy srdlfp from
pharmacies Prescription
dosage form
Dosage
form tablets
Berlin-Chemie / Menarini Germany
Zokardis 7.5 tablets coated.pl.ob. 7.5 mg, 28 pcs. (zofenopril) florida in pharmacy online. Cheap price, instruction, side effects, dosage. Zokardis 7.5 tablets coated.pl.ob. 7.5 mg, 28 pcs. - Sale. PayPal accept. Free shipping florida. Fast international shipping.
Zocardis
Release form
film-coated tablets.
Packing
28 pcs
Pharmacological action
Pharmacodynamics
ACE inhibitor, antihypertensive drug. The mechanism of action is associated with a decrease in the formation of angiotensin II from angiotensin I. A decrease in the content of angiotensin II leads to a direct decrease in the release of aldosterone, while OPSS, systolic and diastolic blood pressure, post- and myocardial preload are reduced. Expands arteries to a greater extent than veins, while a reflex increase in heart rate is not observed. Reduces the degradation of bradykinin, increases the synthesis of prostaglandin.
The antihypertensive effect is more pronounced with a high concentration of plasma renin than with a normal or reduced concentration. A decrease in blood pressure in the therapeutic range does not affect cerebral circulation, blood flow in the vessels of the brain is maintained at a sufficient level and against a background of decreased blood pressure. Enhances coronary and renal blood flow.
With prolonged use, hypertrophy of the left ventricle of the myocardium and myocytes of the walls of the arteries of the resistive type, prevents the progression of heart failure and slows down the development of dilatation of the left ventricle. Improves blood supply to the ischemic myocardium. Reduces platelet aggregation. Zofenopril is a prodrug, because free sulfhydryl compound (zofenoprilat), resulting from thioether hydrolysis, has activity.
After oral administration, the hypotensive effect develops after 1 hour, reaches a maximum after 4-6 hours and lasts up to 24 hours. In some cases, therapy is required for several weeks to achieve an optimal reduction in blood pressure. In heart failure, a noticeable clinical effect is observed with prolonged treatment (6 months or more).
Pharmacokinetics
Absorption and distribution of
After oral administration, zofenopril is rapidly and completely absorbed from the gastrointestinal tract and undergoes almost complete conversion to zofenoprilat.
Cmax of zofenoprilat in blood plasma is achieved 1.5 hours after taking Zokardis. Plasma protein binding for zofenopril is 88%.
Metabolism and excretion
Zofenopril is rapidly metabolized in the liver to form the active metabolite of zofenopril. T1 / 2 of zofenoprilat is 5.5 hours, the total clearance is 1300 ml / min. Zofenoprilat is excreted mainly by the kidneys - 69%, through the intestines - 26%.
Indications
Mild to moderate arterial hypertension.
Acute myocardial infarction with symptoms of heart failure in patients with stable hemodynamics and not receiving thrombolytic therapy.
Contraindications
Hypersensitivity to zofenopril and other ACE inhibitors
angioedema associated with the use of ACE inhibitors, a history of
porphyria
severe liver dysfunction
early pregnancy early
severe renal failure.
Caution is advised to use Zokardis®: with primary hyperaldosteronism, bilateral renal artery stenosis, single kidney artery stenosis, hyperkalemia, condition after kidney transplantation, aortic stenosis, mitral stenosis (with hemodynamic impairment), idiopathic hypertrophic subaortic stenosis, connective tissue disease, cerebrovascular disease, cerebrovascular disease proteinuria more than 1 g / day), liver failure, with simultaneous use with immunosuppressants, in the elderly (art. Arsha 75 years old), with psoriasis.
Caution must be exercised when prescribing the drug to patients with reduced BCC (as a result of diuretic therapy, while restricting salt intake, hemodialysis, diarrhea and vomiting), because increased risk of a sudden and pronounced decrease in blood pressure after the use of an ACE inhibitor, even at the initial dose.
Use during pregnancy and lactation
ZocardiВ® is contraindicated in pregnancy and lactation (breastfeeding).
When using the drug, women of childbearing age should use reliable methods of contraception.
Zofenopril calcium is excreted in breast milk.
Composition
1 tablet contains:
Active substances:
zofenopril calcium 7.5 mg.
Excipients:
lactose monohydrate,
magnesium stearate,
microcrystalline cellulose,
corn starch,
silicon dioxide colloidal.
Shell composition:
hypromellose,
titanium dioxide,
macrogol 400,
macrogol 600.
Dosage and administration of
Tablets are taken orally, regardless of the meal (before, during or after a meal), drinking plenty of fluids.
Arterial hypertension
Patients with normal liver and kidney function
Adults should begin with a dose of 15 mg (2 tablets of 7.5 mg or 1/2 tablet of 30 mg) 1 time / day and gradually to achieve the optimal level of blood pressure. , with insufficient severity of the hypotensive effect, increase the dose with an interval of 4 weeks.
The average dose is 30 mg 1 time / day (4 tablets of 7.5 mg or 1 tablet of 30 mg).
The maximum daily dose is 60 mg (8 tablets of 7.5 mg or 2 tablets of 30 mg). Multiplicity of admission is 1-2 times / day.
Patients with impaired water-electrolyte balance
Before prescribing ACE inhibitors, correction of water-electrolyte metabolism and cancellation of diuretic therapy 2–3 days before the start of ACE inhibitor are required. In this case, the initial dose of Zocardis is 15 mg / day. If the abolition of diuretics and normalization of the water-electrolyte balance is not possible, then the initial dose of Zokardis should be 7.5 mg / day.
Patients with impaired renal function or undergoing hemodialysis
Zocardis dose adjustment is required. With KK> 45 ml / min dose adjustment is not performed, with KK < 45 ml / min dose should be reduced to 1/2 the average therapeutic dose 1 time / day.
The starting dose for dialysis patients is 1/4 of the dose used for patients with normal renal function.
Elderly patients
With normal renal function, dosage adjustment in the elderly is not required. Elderly patients with CC <45 ml / min are recommended 1/2 of the average therapeutic dose.
Patients with impaired liver function
In patients with mild to moderate hepatic insufficiency, the initial dose of Zokardis® is 1/2 the dose used in patients with normal liver function.
Patients with severe hepatic impairment
Zokardis® is not prescribed.
Acute myocardial infarction
Treatment with Zokardis® is started within 24 hours after the onset of the first symptoms of myocardial infarction and continues for 6 weeks, with the following regimen applied:
Time period 1 and 2 days 7.5 mg every 12 hours (dosing regimen).
Time period 3rd and 4th day, 15 mg every 12 hours (dosing regimen).
Time period from the 5th day onwards to 30 mg every 12 hours (dosing regimen).
With an excessive decrease in blood pressure at the beginning of treatment or during the first 3 days after myocardial infarction, the initial dose is not increased or the drug is canceled.
After 6 weeks of treatment, therapy may be discontinued in patients with no evidence of left ventricular failure or heart failure. For the correction of left ventricular failure or heart failure, as well as hypertension, treatment can be continued for a long time.
Dosage in elderly patients with acute myocardial infarction
Zokardis® should be used with caution in patients with myocardial infarction older than 75 years.
Side effects of
From the cardiovascular system: excessive decrease in blood pressure, orthostatic collapse rarely - pain behind the sternum, angina pectoris, myocardial infarction (usually associated with a pronounced decrease in blood pressure), arrhythmias (atrial brady or tachycardia, atrial fibrillation), palpitations, thromboembolism of the branches of the pulmonary artery, pain in the heart, fainting.
From the side of the central nervous system and peripheral nervous system: dizziness, headache, weakness, insomnia, anxiety, depression, confusion, increased fatigue, drowsiness (2-3%) is very rare (when used in high doses) - nervousness, paresthesia.
On the part of the sensory organs: rarely - disturbances in the vestibular apparatus, impaired hearing and vision, tinnitus.
From the digestive system: dry mouth, anorexia, dyspeptic disorders (nausea, diarrhea or constipation, vomiting, abdominal pain), increased activity of liver transaminases, hyperbilirubinemia, intestinal obstruction, pancreatitis, impaired liver function, disorders of the biliary tract, hepatitis, jaundice.
From the respiratory system: unproductive dry cough is very rare - interstitial pneumonitis, bronchospasm, shortness of breath, rhinorrhea, pharyngitis.
From the hemopoietic system: in some cases, thrombocytopenia, neutropenia, agranulocytosis (in patients with autoimmune diseases), eosinophilia.
From the urinary system: increased creatinine and urea, impaired renal function, proteinuria.
On the part of laboratory indicators: hypercreatinemia, increased urinary levels, increased activity of AST, ALT, hyperbilirubinemia, hyperkalemia, hyponatremia, in some cases, decreased hematocrit and decreased hemoglobin, increased ESR, thrombocytopenia, neutropenia, agranulocytosis, and patients with .
Allergic reactions: rarely - skin rash, angioedema (face, limbs, lips, tongue, glottis and / or larynx), dysphonia, polymorphic erythema, exfoliative dermatitis very rarely - Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell syndrome) , pemphigus, itching, urticaria, photosensitivity, serositis, vasculitis, myositis, arthralgia, arthritis, stomatitis, glossitis.
Drug Interaction
When used jointly, the antihypertensive effect of ACE inhibitors may be enhanced by other antihypertensive agents, diuretics, general anesthesia agents, antipyretics, ethanol.
When administered with NSAIDs, the antihypertensive effect of zofenopril may be reduced.
Hyperkalemia may occur when co-administered with potassium-sparing diuretics.
When used simultaneously with lithium salts, there is a slowdown in lithium removal.
When used together with immunosuppressants, allopurinol, cytostatics enhance the hematotoxicity of zofenopril.
When administered with hypoglycemic agents, the risk of hypoglycemia increases.
Overdose
Symptoms: marked decrease in blood pressure (up to the development of collapse, myocardial infarction, acute disorders of cerebral circulation or thromboembolic complications), convulsions, stupor.
Treatment: the patient is transferred to a horizontal position with a low head. In mild cases - gastric lavage and intake of saline solution, in more severe cases, measures aimed at stabilizing blood pressure (in / in the introduction of 0.9% sodium chloride solution, plasma substitutes), if necessary - the introduction of angiotensin II, hemodialysis.
Storage conditions
Keep out of the reach of children at a temperature not exceeding 25 ° C.
Expiration
3 years.
Deystvuyuschee substances
zofenopril
Terms of sale from pharmacies s17lfpd17 pharmacy srdlfp from
pharmacies Prescription
dosage form
Dosage
form tablets
Berlin-Chemie / Menarini Germany
Zokardis 7.5 tablets coated.pl.ob. 7.5 mg, 28 pcs. (zofenopril) florida in pharmacy online. Cheap price, instruction, side effects, dosage. Zokardis 7.5 tablets coated.pl.ob. 7.5 mg, 28 pcs. - Sale. PayPal accept. Free shipping florida. Fast international shipping.
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